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OECD-ISO Joint Meeting Report highlights Need for Updates to OECD Test Guidelines

The Organisation for Co-operation and Development (OECD) has released a new document, Report of the OECD Expert Meeting on the Physical Chemical Properties of Manufactured Nanomaterials and Test Guidelines. The meeting, which brought together members of the OECD Working Party on Manufactured Nanomaterials (WPMN) and the International Organization for Standardization (ISO) Technical Committee on Nanotechnologies (TC/229), took place in Mexico between 28 Feb 2013 and 1 March 2013, and was attended by NIA. The report presents an overview of ‘the discussion and recommendations derived from the workshop’, and is number 41 in the OECD Series on the Safety of Manufactured Nanomaterials.

There were two objectives for the workshop: the first was to ‘assess the applicability of existing OECD Test Guidelines on physical-chemical properties of manufactured nanomaterials’; the second was to ‘identify the need to update current or develop new OECD Test Guidelines and/or OECD Guidance Documents which are relevant for safety and regulatory decision-making’. Discussion focused on four selected categories of endpoints:

  1. ‘State of dispersion, aggregation and agglomeration of nanomaterials
  2. Size (and size distribution) of nanoparticles
  3. Surface area and porosity
  4. Surface reactivity

Some of the main conclusions from the discussion included:

  • A new test guideline for dispersion/agglomeration/aggregation which can refer to existing ISO standards. This guideline ‘would have to specify the intended use of the measurements, and define the relevant dispersion protocols for the different end-points for which dispersion/aggregation/agglomeration need to be assessed’
  • Test Guideline 105 on water solubility ‘needs to be revised and refined’
  • A new Test Guideline and Technical Standard were recommended for zeta potentials. The guideline ‘would have to specify the exact intended use of the measurements, and define the relevant dispersion protocols for the different end-points for which zeta potential would need to be assessed’
  • An agreement that ‘there is sufficient information to move forward with a technical standard for a BET method for metal oxide nanomaterials’

 

Follow this link to read the full report, and this to access the OECD Series on the Safety of Manufactured Nanomaterials.

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